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J Virol. 2012 Mar;86(5):2878-81. doi: 10.1128/JVI.06623-11. Epub 2011 Dec 14.

Immune correlates of herpes zoster in HIV-infected children and youth.

Author information

1
University of Colorado Denver, Aurora, Colorado, USA. adriana.weinberg@ucdenver.edu

Abstract

To identify immunologic factors that modulate the risk of herpes zoster (HZ), we compared varicella-zoster virus (VZV)-specific and nonspecific T-cell subpopulations of 47 HIV-infected children before they developed HZ with those of 141 VZV-positive HZ-negative matched controls. Compared with controls, HZ cases had lower VZV-specific CD8(+) CD107a(+) cell percentages independently of CD4(+) percentages or HIV loads, suggesting that VZV-specific cytotoxic T cells are protective against HZ. In contrast, high nonspecific regulatory and activated T cells were associated with an increased risk of HZ.

PMID:
22171274
PMCID:
PMC3302278
DOI:
10.1128/JVI.06623-11
[Indexed for MEDLINE]
Free PMC Article
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