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Dig Liver Dis. 2012 Apr;44(4):350-4. doi: 10.1016/j.dld.2011.10.017. Epub 2011 Nov 25.

Safety and outcome of chemoradiotherapy in elderly patients with rectal cancer: results from two French tertiary centres.

Author information

1
Department of Gastroenterology, Poitiers University Hospital, Cancéropôle Grand Ouest, Poitiers, France. davidtougeron@hotmail.fr

Abstract

BACKGROUND:

The risks of chemoradiotherapy in elderly patients with rectal cancer have not yet been well-characterised.

METHODS:

We retrospectively reviewed the charts of patients with rectal cancer over 70 years old who were treated with chemoradiotherapy in two French university hospitals.

RESULTS:

A total of 125 patients were evaluated. Mean age was 75.1 ± 4.1 years and ranged from 70 to 90 years. Adverse effects ≥ grade 2 were observed in 32% of the patients and adverse effects ≥ grade 3 in 15%. Dose reduction for toxicity was performed in 18% of the patients and chemoradiotherapy discontinuation was necessary in 9%. Postoperative morbidity was 16% with two treatment-related deaths. Two-year survival rate was 84%. No variables had any influence on treatment-related adverse events.

CONCLUSIONS:

In selected elderly patients, chemoradiotherapy is well-tolerated, without any significant increase in adverse events, and the results are similar to those recorded in younger patients.

PMID:
22119617
DOI:
10.1016/j.dld.2011.10.017
[Indexed for MEDLINE]

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