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Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12529-33. doi: 10.1002/anie.201103728. Epub 2011 Nov 4.

Electrochemical control of growth factor presentation to steer neural stem cell differentiation.

Author information

1
Cell and Molecular Biology, Karolinska Institute von Eulers väg 3, 17177 Solna, Sweden. anna.herland@ki.se

Abstract

Let it grow: The conjugated polymer poly(3,4-ethylenedioxythiophene) (PEDOT) was synthesized with heparin as the counterion to form a cell culture substrate. The surface of PEDOT:heparin in the neutral state associated biologically active growth factors. Electrochemical in situ oxidation of PEDOT during live cell culture decreased the bioavailability of the growth factor and created an exact onset of neural stem cell differentiation.

PMID:
22057546
DOI:
10.1002/anie.201103728
[Indexed for MEDLINE]
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