Format

Send to

Choose Destination
Behav Brain Res. 2012 Feb 14;227(2):497-507. doi: 10.1016/j.bbr.2011.10.009. Epub 2011 Oct 18.

New neurons in an aged brain.

Author information

1
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

Adult hippocampal neurogenesis is one of the most robust forms of synaptic plasticity in the nervous system and occurs throughout life. However, the rate of neurogenesis declines dramatically with age. Older animals have significantly less neural progenitor cell proliferation, neuronal differentiation, and newborn neuron survival compared to younger animals. Intrinsic properties of neural progenitor cells, such as gene transcription and telomerase activity, change with age, which may contribute to the observed decline in neurogenesis. In addition, age-related changes in the local cells of the neurogenic niche may no longer provide neural progenitor cells with the cell-cell contact and soluble cues necessary for hippocampal neurogenesis. Astrocytes, microglia, and endothelial cells undergo changes in morphology and signaling properties with age, altering the foundation of the neurogenic niche. While most studies indicate a correlation between decreased hippocampal neurogenesis and impaired performance in hippocampus-dependent cognitive tasks in aged mice, a few have demonstrated that young and aged mice are equivalent in their cognitive ability. Here, we summarize the different behavioral paradigms to test hippocampus-dependent cognition and the need to develop neurogenesis-dependent tasks.

PMID:
22024433
PMCID:
PMC3264739
DOI:
10.1016/j.bbr.2011.10.009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center