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Appl Physiol Nutr Metab. 2011 Dec;36(6):996-1000. doi: 10.1139/h11-091. Epub 2011 Oct 20.

Nitric oxide synthase inhibition delays low-frequency stimulation-induced satellite cell activation in rat fast-twitch muscle.

Author information

1
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB T6G 2H9, Canada.

Abstract

This study examined the effect of nitric oxide synthase (NOS) inhibition via N(ω)-nitro-l-arginine methyl ester (l-NAME) administration on low-frequency stimulation-induced satellite cell (SC) activation in rat skeletal muscle. l-NAME only delayed stimulation-induced increases in SC activity. Also, stimulation-induced increases in hepatocyte growth factor (HGF) mRNA and protein expression were only abrogated at the mRNA level in l-NAME-treated animals. Therefore, early stimulation-induced SC activation appears to be NOS-dependent, while continued activation may involve NOS-independent HGF translational control mechanisms.

PMID:
22014180
DOI:
10.1139/h11-091
[Indexed for MEDLINE]

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