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J Perinatol. 2012 Jun;32(6):431-7. doi: 10.1038/jp.2011.115. Epub 2011 Aug 18.

Consanguinity, prematurity, birth weight and pregnancy loss: a prospective cohort study at four primary health center areas of Karnataka, India.

Author information

1
Department of Medical Education, Jawaharlal Nehru Medical College, Belgaum, India.

Abstract

OBJECTIVE:

To determine whether consanguinity adversely influences pregnancy outcome in South India, where consanguinity is a common means of family property retention.

STUDY DESIGN:

Data were collected from a prospective cohort of 647 consenting women, consecutively registered for antenatal care between 14 and 18 weeks gestation, in Belgaum district, Karnataka in 2005. Three-generation pedigree charts were drawn for consanguineous participants. χ (2)-Test and Student's t-test were used to assess categorical and continuous data, respectively, using SPSS version 14. Multivariate logistic regression adjusted for confounding variables.

RESULT:

Overall, 24.1% of 601 women with singleton births and outcome data were consanguineous. Demographic characteristics between study groups were similar. Non-consanguineous couples had fewer stillbirths (2.6 vs 6.9% P=0.017; adjusted P=0.050), miscarriages (1.8 vs 4.1%, P=0.097; adjusted P=0.052) and lower incidence of birth weight <2500 g (21.8 vs 29.5%, P=0.071, adjusted P=0.044). Gestation <37 weeks was 6.2% in both the groups. Adjusted for consanguinity and other potential confounders, age <20 years was protective of stillbirth (P=0.01), pregnancy loss (P=0.023) and preterm birth (P=0.013), whereas smoking (P=0.015) and poverty (P=0.003) were associated with higher rates of low birth weight.

CONCLUSION:

Consanguinity significantly increases pregnancy loss and birth weight <2500 g.

PMID:
21852769
DOI:
10.1038/jp.2011.115
[Indexed for MEDLINE]

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