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Hum Mol Genet. 2011 Oct 15;20(R2):R109-15. doi: 10.1093/hmg/ddr336. Epub 2011 Aug 9.

Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.

Author information

1
Laboratory of Genetics (LOG-G), The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.

PMID:
21828073
PMCID:
PMC4447776
DOI:
10.1093/hmg/ddr336
[Indexed for MEDLINE]
Free PMC Article

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