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PLoS One. 2011;6(6):e21756. doi: 10.1371/journal.pone.0021756. Epub 2011 Jun 29.

Memory B cells and CD8⁺ lymphocytes do not control seasonal influenza A virus replication after homologous re-challenge of rhesus macaques.

Author information

1
Center for Comparative Medicine, University of California Davis, Davis, California, United States of America.

Abstract

This study sought to define the role of memory lymphocytes in the protection from homologous influenza A virus re-challenge in rhesus macaques. Depleting monoclonal antibodies (mAb) were administered to the animals prior to their second experimental inoculation with a human seasonal influenza A virus strain. Treatment with either anti-CD8α or anti-CD20 mAbs prior to re-challenge had minimal effect on influenza A virus replication. Thus, in non-human primates with pre-existing anti-influenza A antibodies, memory B cells and CD8α⁺ T cells do not contribute to the control of virus replication after re-challenge with a homologous strain of influenza A virus.

PMID:
21747924
PMCID:
PMC3126839
DOI:
10.1371/journal.pone.0021756
[Indexed for MEDLINE]
Free PMC Article

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