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J Innate Immun. 2011;3(4):403-10. doi: 10.1159/000328011. Epub 2011 May 25.

Natural killer cells in psoriasis.

Author information

1
Department of Dermatology, St Vincent's University Hospital, Dublin, Ireland. tobin.annemarie@gmail.com

Abstract

Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions, natural killer and natural killer T cells appear to have a unique role. We review the evidence supporting a role for natural killer cells in psoriasis.

PMID:
21613780
DOI:
10.1159/000328011
[Indexed for MEDLINE]
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