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Am J Obstet Gynecol. 2011 Jun;204(6):496.e1-6. doi: 10.1016/j.ajog.2011.02.018. Epub 2011 Apr 14.

Postpartum factors and natural fibroid regression.

Author information

1
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.

Abstract

OBJECTIVE:

Many fibroids regress with pregnancy or postpartum involution. We sought to identify factors that might inhibit or enhance this natural regression.

STUDY DESIGN:

We used a prospective cohort of women with fibroids (n = 494) determined by ultrasound screening during the early first trimester identified from the Right from the Start study. Ultrasounds were repeated 3-6 months postpartum (n = 279). Logistic regression analyses were used to identify factors associated with fibroid regression (>50% reduction in volume).

RESULTS:

Postpartum progestin users had significantly less fibroid regression (P = .01), whereas there was no association for combined estrogen-progestin use. Cesarean delivery and fever (hypothesized to inhibit regression) and breast feeding (hypothesized to enhance regression) were not associated with fibroid regression.

CONCLUSION:

Progestin use in the postpartum period may limit regression of fibroids, consistent with prior literature on progesterone's role in fibroid development. Research into progestin-only treatments in critical reproductive periods is needed.

PMID:
21492823
PMCID:
PMC3136622
DOI:
10.1016/j.ajog.2011.02.018
[Indexed for MEDLINE]
Free PMC Article
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