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Aging (Albany NY). 2011 Apr;3(4):391-4.

Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster.

Author information

1
Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia. amoskalev@ib.komisc.ru

Abstract

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

PMID:
21483034
PMCID:
PMC3117454
DOI:
10.18632/aging.100314
[Indexed for MEDLINE]
Free PMC Article

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