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Clin Ophthalmol. 2011;5:345-51. doi: 10.2147/OPTH.S17335. Epub 2011 Mar 10.

Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy.

Author information

1
Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan;

Abstract

PURPOSE:

To investigate the structural changes in the photoreceptors by adaptive optics (AO) fundus imaging and Fourier-domain optical coherence tomography (FD-OCT) in eyes with occult macular dystrophy (OMD).

DESIGN:

Observational case reports.

METHODS:

Eight eyes of four patients who were diagnosed with OMD were examined. All eyes had a complete ophthalmological examination. Multifocal electroretinograms (mfERGs) were recorded from all eyes. AO and FD-OCT images of foveal photoreceptors were obtained.

RESULTS:

The best-corrected visual acuity (BCVA) of these eyes ranged from 20/20 to 20/200, and the ocular fundus was normal by conventional ocular examination in all eyes. The amplitudes of the mfERGs were decreased in the foveal area. The inner and outer segment (IS/OS) junction of the photoreceptors in the foveal area was disrupted. The IS/OS junction was intact in one eye with a BCVA of 20/20, and the outer segment layer between the IS/OS junction and retinal pigment epithelium of the FD-OCT images was identified only in the center of the fovea. The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.

CONCLUSION:

Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.

KEYWORDS:

OMD; Photoreceptors; images; retinal imaging

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