Send to

Choose Destination
Transcription. 2011 Mar;2(2):55-59.

The core human mitochondrial transcription initiation complex: It only takes two to tango.

Author information

Department of Pathology Yale University School of Medicine; New Haven, CT USA.


We recently demonstrated that the core transcription initiation complex in human mitochondria is a two-component system (POLRMT and h-mtTFB2). Human mtTFA/TFAM, previously proposed to be a requisite initiation complex member, is dispensable for promoter-specific initiation in vitro. We propose that it instead regulates relative promoter activity and/or overall nucleoid transcription and replication potential.

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center