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Acad Radiol. 2011 Jul;18(7):837-41. doi: 10.1016/j.acra.2011.02.005. Epub 2011 Mar 21.

A comparison of mean displacement values using high b-value Q-space diffusion-weighted MRI with conventional apparent diffusion coefficients in patients with stroke.

Author information

1
Department of Radiology, University of Yamanashi, Yamanashi, Japan. mahori@juntendo.ac.jp

Abstract

RATIONALE AND OBJECTIVES:

Q-space analysis using high b-value diffusion-weighted magnetic resonance (MR) data provides information on tissue microstructure in contrast to conventional MR imaging (MRI) based on low b-value diffusion-weighted imaging (DWI). The purpose of this study was to evaluate the use of mean displacement (MDP) map in stroke patients using q-space diffusion-weighted MRI (QSI).

MATERIALS AND METHODS:

Twenty-one patients presenting with a total of 22 acute or subacute cerebral infarctions were included. MR protocol consisted of conventional MR sequences, DWI (b-value; 1000 s/mm(2)) and QSI (b-value; maximum 12,000 s/mm(2)). Apparent diffusion coefficient (ADC) maps of conventional DWI and MDP maps of QSI data were obtained and compared in the ischemic lesions and corresponding normal tissues.

RESULTS:

Decreased ADC values were present in all lesions. There was no correlation between ADC and MDP values in the lesions (r = 0.21). MDP values of the lesions were 8.60 ± 1.26 μm (mean ± SD). Most of the lesions (16/22) had higher MDP values than normal brain tissue. Three lesions showed lower MDP values and three showed mixed MDP values.

CONCLUSIONS:

The MDP maps using QSI data provides additional information for stroke patients compared to conventional DWI.

PMID:
21419670
DOI:
10.1016/j.acra.2011.02.005
[Indexed for MEDLINE]

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