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Probl Vet Med. 1990 Dec;2(4):591-601.

Problems in diabetes mellitus management. Insulin resistance.

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Department of Veterinary Physiology, Pharmacology & Toxicology, School of Veterinary Medicine, Lousiana State University, Baton Rouge 70803.


Insulin resistance is a cause for morning hyperglycemia seen in diabetic patients. Other reasons for morning hyperglycemia should be eliminated by performing an insulin response test. Once insulin resistance has been established as the cause of hyperglycemia, a step-by-step process should be used to establish the cause of the insulin resistance. Common causes of insulin resistance include hyperadrenocorticism, acromegaly, hyperthyroidism, and obesity. Hepatic disease, renal insufficiency, and sepsis are other causes of insulin resistance in practice. Less common causes include insulin antibodies, pregnancy, neoplasia, hyperandrogenism, and pheochromocytoma. If the underlying cause cannot be found or resolved, then increased doses of insulin are required to manage the hyperglycemia.

[Indexed for MEDLINE]

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