Abstract
An important role in the interaction between protozoan parasite Leishmania and host is determined by serum factors. The activation of complement can have resistance-promoting effects (due to the lysis of parasite) or disease-promoting effect (due to the opsonization of Leishmania). Also lymphokines can determine resolution or progression of the infection. Particularly, gamma-interferon "in vitro" increases the killing of the parasite and "in vivo" cures cutaneous leishmaniasis.
MeSH terms
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Animals
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Complement Activation*
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Host-Parasite Interactions*
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Humans
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Immunologic Factors / therapeutic use
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Interferon-gamma / physiology
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Interferon-gamma / therapeutic use
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Leishmania / growth & development
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Leishmania / immunology
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Leishmaniasis / blood*
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Leishmaniasis / immunology
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Leishmaniasis, Cutaneous / therapy
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Lymphokines / physiology*
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Lymphokines / therapeutic use
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Mice
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Mice, Inbred BALB C
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Recombinant Proteins
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T-Lymphocyte Subsets / immunology
Substances
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Immunologic Factors
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Lymphokines
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Recombinant Proteins
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Interferon-gamma