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Biochemistry (Mosc). 2010 Nov;75(11):1383-7.

Effect of plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) on contents of steroid hormones and NO level in rats.

Author information

1
Research Institute of Biology, Southern Federal University, Rostov-na-Donu 344090, Russia. vladimirchi@yandex.ru

Erratum in

  • Biochemistry (Mosc). 2011 Jun;76(6):726.

Abstract

Introduction of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) into male Wistar rats once a day for two weeks in doses of 25 and 250 nmol/kg led to elevation of 17β-estradiol level in blood serum by 33 and 41%, respectively. At the same time, nitrate and nitrite contents in the rat blood serum increased by 49 and 34%, respectively. ESR spectroscopy with diethyldithiocarbamateiron complex as a spin trap showed more than twofold increase in NO production in lungs, but not in blood, liver, and intestines, following the SkQ1 daily introduction at a dose of 25 nmol/kg.

PMID:
21314606
[Indexed for MEDLINE]

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