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Mol Biosyst. 2011 Apr;7(4):1046-9. doi: 10.1039/c0mb00324g. Epub 2011 Jan 31.

A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands.

Author information

1
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA, USA.

Abstract

Nuclear receptors are ligand-regulated transcription factors that control a range of (patho)physiological processes. Lipids are the most common type of nuclear receptor ligands. Here, we utilize a metabolomics approach that detects protein-metabolite interactions to identify endogenous peroxisome proliferator-activated receptor (PPAR) ligands from tissue and cell extracts.

PMID:
21283866
DOI:
10.1039/c0mb00324g
[Indexed for MEDLINE]

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