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Front Biosci (Landmark Ed). 2011 Jan 1;16:898-936.

Tight junctions in cancer metastasis.

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  • 1Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.


Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis.

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