Format

Send to

Choose Destination
Neural Comput. 2011 Mar;23(3):651-5. doi: 10.1162/NECO_a_00087. Epub 2010 Dec 16.

Intracellular dynamics of virtual place cells.

Author information

1
Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel sandro.romani@gmail.com.

Abstract

The pattern of spikes recorded from place cells in the rodent hippocampus is strongly modulated by both the spatial location in the environment and the theta rhythm. The phases of the spikes in the theta cycle advance during movement through the place field. Recently intracellular recordings from hippocampal neurons (Harvey, Collman, Dombeck, & Tank, 2009 ) showed an increase in the amplitude of membrane potential oscillations inside the place field, which was interpreted as evidence that an intracellular mechanism caused phase precession. Here we show that an existing network model of the hippocampus (Tsodyks, Skaggs, Sejnowski, & McNaughton, 1996 ) can equally reproduce this and other aspects of the intracellular recordings, which suggests that new experiments are needed to distinguish the contributions of intracellular and network mechanisms to phase precession.

PMID:
21162664
PMCID:
PMC3161172
DOI:
10.1162/NECO_a_00087
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center