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Am J Obstet Gynecol. 2011 Mar;204(3):238.e1-5. doi: 10.1016/j.ajog.2010.10.005. Epub 2010 Dec 8.

Use of oxytocin during early stages of labor and its effect on active management of third stage of labor.

Author information

1
Department of Obstetrics and Gynecology, School of Medicine, University of Uruguay, Montevideo, Uruguay. csosa@tulane.edu

Abstract

OBJECTIVE:

The purpose of this study was to evaluate whether the use of oxytocin during the first and second stages of labor is associated with a higher incidence of postpartum hemorrhage (PPH) in pregnant women who received active management of third stage of labor (AMTSL).

STUDY DESIGN:

A secondary data analysis from vaginal deliveries in a hospital-based cohort study from 24 maternity hospitals in South America. The primary outcomes that were analyzed were moderate PPH (≥500 mL of blood loss), severe PPH (≥1000 mL of blood loss), and need of blood transfusion.

RESULTS:

A total of 11,323 vaginal deliveries were included. The incidence of moderate and severe PPH was 10.8% and 1.86%, respectively. Overall, 36% of deliveries received AMTSL. There was no association between induced/augmented labor and moderate PPH (P = .753), severe PPH (P = .273), and blood transfusion (P = .603) in the population that received AMTSL.

CONCLUSION:

AMTSL should be recommended, regardless of whether pregnant women received oxytocin during the first and second stages of labor.

PMID:
21145034
PMCID:
PMC3057346
DOI:
10.1016/j.ajog.2010.10.005
[Indexed for MEDLINE]
Free PMC Article

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