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Acta Cytol. 2011;55(1):106-12. doi: 10.1159/000320924. Epub 2010 Nov 26.

Comparison of self-collected and clinician-collected materials for cervical cytology and human papillomavirus genotyping: analysis by linear array assay.

Author information

1
School of Health Sciences, Faculty of Medicine, Department of Diagnostic Pathology, Gunma University, Tomioka General Hospital, Gunma, Japan. toyosida@health.gunma-u.ac.jp

Abstract

OBJECTIVE:

This study compared the usefulness of self-collected (SC) and clinician-collected (CC) materials for cervical cytology and human papillomavirus (HPV) genotyping.

STUDY DESIGN:

Fifty women with previous positive cytology and who were undergoing regular checkups were included in the study. CC samples were collected using a Cervex-Brush Combi with liquid-based cytology. One month later, SC material was acquired using the Rovers Viba-brush vaginal sampler, and fixed at home. Thin-layer specimens were prepared from both samples and HPV status was analyzed using a linear array.

RESULTS:

A total of 37/50 CC (74%) and 41/50 SC (82%) cases were positive for HPV. Pap tests identified high-grade squamous intraepithelial lesions in 11 (22%) and seven (14%) patients, low-grade squamous intraepithelial lesions in 19 (38%) and 16 (32%), atypical squamous cells of undetermined significance in 2 (4%) and 0 patients, and NILM (negative for intraepithelial lesion or malignancy) in 18 (36%) and 27 (54%) patients in the CC and SC groups, respectively.

CONCLUSIONS:

SC material had a lower positive cytology rate, but a higher HPV-positive rate than CC material. These results suggest that a combination of Pap and HPV tests on SC material may provide a diagnostic strategy with high sensitivity and specificity.

PMID:
21135530
DOI:
10.1159/000320924
[Indexed for MEDLINE]

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