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Cell Metab. 2010 Dec 1;12(6):559-60. doi: 10.1016/j.cmet.2010.11.018.

Stressed-out mitochondria get MAD.

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Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.


Mechanisms maintaining mitochondrial integrity range from specific repair pathways to wholesale degradation of damaged organelles. A recent study in Molecular Cell (Heo et al., 2010) adds another mechanism to this mitochondrial homeostasis toolkit: mitochondria-associated protein degradation (MAD) that ultimately directs endoplasmic reticulum-associated protein degradation (ERAD) pathway components to oxidatively stressed mitochondria.

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