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Fitoterapia. 2011 Apr;82(3):331-41. doi: 10.1016/j.fitote.2010.11.002. Epub 2010 Nov 9.

Tithonia diversifolia and its main active component tagitinin C induce survivin inhibition and G2/M arrest in human malignant glioblastoma cells.

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Department and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.


We investigated the antitumour activity of Tithonia diversifolia (TD) on malignant glioblastoma cells. Our results suggested that tagitinin C was the main component in viability inhibition on malignant glioblastoma cells, and also accounted to be the most abundant component (>65%) in TD extract. Both TD extract and tagitinin C exhibited vigorous potential to produce in vitro viability inhibition, autophagic cell death and G2/M arrest. Furthermore, the activity of survivin, a critical resistant-factor in cancer therapy, could be downregulated significantly by TD extract and tagitinin C. These findings suggested that TD extract and tagitinin C were effective for treating malignant glioblastoma.

[Indexed for MEDLINE]

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