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Arch Pharm Res. 2010 Jun;33(6):875-80. doi: 10.1007/s12272-010-0610-x. Epub 2010 Jul 6.

Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase in vitro.

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Diabetic Complications Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea.


In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines, fifteen compounds, apigenin (1), apigenin-7-O-beta-D: -glucopyranoside (2), apigenin-7-O-(6''-O-acetyl)-beta-D: -glucopyranoside (3), luteolin (4), luteolin-7-O-beta-D: -glucopyranoside (5), luteolin-7-O-(6''-O-acetyl)-beta-D: -glucopyranoside (6), isorhamnetin-3-Oneohesperidoside (7), 4-O-caffeoylquinic acid (8), chlorogenic acid methyl ester (9), 4-O-beta-D: -glucopyranosylcaffeic acid (10), lobetyolin (11), cordifolioidyne C (12), isomultiflorenyl acetate (13), beta-sitosterol glucoside (14), and alpha-spinosterol (15), were isolated from an EtOAc-soluble fraction of the flowers of Platycodon grandiflorum (balloonflower; Campanulaceae). The structures of the compounds were identified by physical and spectroscopic methods, as well as by comparison of their data with literature values. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products and rat lens aldose reductase.

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