Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp

Yuji Kon; Takaaki Kubota; Azusa Shibazaki; Tohru Gonoi; Jun'ichi Kobayashi

doi:10.1016/j.bmcl.2010.06.015

Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4569-72. doi: 10.1016/j.bmcl.2010.06.015. Epub 2010 Jun 8.

Authors

Yuji Kon¹, Takaaki Kubota, Azusa Shibazaki, Tohru Gonoi, Jun'ichi Kobayashi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 20584605
DOI: 10.1016/j.bmcl.2010.06.015

Abstract

Three new bromotyrosine alkaloids, ceratinadins A-C (1-3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1-3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety. Ceratinadins A (1) and B (2) showed antifungal activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Alkaloids / pharmacology
Animals
Antifungal Agents / chemistry*
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology
Imidazoles / chemistry*
Imidazoles / isolation & purification
Imidazoles / pharmacology
Magnetic Resonance Spectroscopy
Molecular Conformation
Porifera / chemistry*
Quinolines / chemistry*
Quinolines / isolation & purification
Quinolines / pharmacology
Tyrosine / analogs & derivatives*
Tyrosine / chemistry

Substances

Alkaloids
Antifungal Agents
Imidazoles
Quinolines
bromotyrosine
ceratinadin A
ceratinadin B
ceratinadin C
Tyrosine