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Pharmacol Ther. 2010 Aug;127(2):156-64. doi: 10.1016/j.pharmthera.2010.04.012. Epub 2010 May 28.

A survey of yeast genomic assays for drug and target discovery.

Author information

1
Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

Abstract

Over the past decade, the development and application of chemical genomic assays using the model organism Saccharomyces cerevisiae has provided powerful methods to identify the mechanism of action of known drugs and novel small molecules in vivo. These assays identify drug target candidates, genes involved in buffering drug target pathways and also help to define the general cellular response to small molecules. In this review, we examine current yeast chemical genomic assays and summarize the potential applications of each approach.

PMID:
20546776
PMCID:
PMC2923554
DOI:
10.1016/j.pharmthera.2010.04.012
[Indexed for MEDLINE]
Free PMC Article

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