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Curr Opin Neurobiol. 2010 Aug;20(4):416-23. doi: 10.1016/j.conb.2010.04.010. Epub 2010 May 12.

Signaling in adult neurogenesis.

Author information

1
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

Neural stem cells (NSCs) in the adult brain continuously supply new neurons to the hippocampal dentate gyrus (DG) and the olfactory bulb (OB). Recent studies indicate that the progression from neural precursor cells (NPCs) to mature neurons is tightly controlled by coordinate cell-intrinsic programs and external signals within the neurogenic niche. In this review, we summarize both classes of regulatory factors involved in distinct stages of adult neurogenesis, including proliferation and lineage differentiation of NSCs, migration of neuroblasts and integration of newborn neurons. A full understanding of the wide variety of signaling pathways will ultimately provide precise targets for therapeutic applications.

PMID:
20471243
PMCID:
PMC2942965
DOI:
10.1016/j.conb.2010.04.010
[Indexed for MEDLINE]
Free PMC Article

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