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Trends Microbiol. 2010 Jul;18(7):323-30. doi: 10.1016/j.tim.2010.04.003. Epub 2010 May 6.

Targeting a host process as an antiviral approach against dengue virus.

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Department of Genetics and Biochemistry, Clemson University, 217 Biosystems Research Complex, 51 New Cherry Street, Clemson, SC 29634, USA.


The re-emergence of dengue virus as a significant human pathogen has lead to an increasing need for effective antivirals. Development of therapeutic agents with the ability to attenuate both the duration and severity of disease in patients after infection is particularly desirable in dengue endemic resource-poor settings. The reliance of dengue virus on endogenous processes during the late stages of infection prompts the development of molecules to interfere with and exploit these dependencies as potential antiviral therapies. Here we focus on the importance of N-linked glycan processing in infectious virion morphogenesis.

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