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Trends Biochem Sci. 2010 Aug;35(8):442-9. doi: 10.1016/j.tibs.2010.03.004. Epub 2010 Apr 8.

PTP1B: a double agent in metabolism and oncogenesis.

Author information

1
Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

Abstract

PTP1B, a non-transmembrane protein tyrosine phosphatase that has long been studied as a negative regulator of insulin and leptin signaling, has received renewed attention as an unexpected positive factor in tumorigenesis. Here, we highlight how views of this enzyme have evolved from regarding it as a simple metabolic off-switch to a more complex view of PTP1B as an enzyme that can play both negative and positive roles in diverse signaling pathways. These dual characteristics make PTP1B a particularly attractive therapeutic target for diabetes, obesity, and perhaps breast cancer.

PMID:
20381358
PMCID:
PMC2917533
DOI:
10.1016/j.tibs.2010.03.004
[Indexed for MEDLINE]
Free PMC Article

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