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Wilms Tumor Predisposition.

Authors

Dome JS1, Huff V2.

Source

GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2003 Dec 19 [updated 2016 Oct 20].

Author information

1
Children’s National Health System, Washington, DC
2
Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas

Excerpt

PURPOSE:

This GeneReview is intended to help clinicians determine if a genetic basis can be identified in an individual with Wilms tumor in order to provide families with natural history and recurrence risk information.

GOAL 1:

Briefly describe the clinical characteristics of Wilms tumor.

GOAL 2:

Review the mechanisms of predisposition to Wilms tumor.

GOAL 3:

Provide an evaluation strategy to: Determine if a proband with Wilms tumor has a predisposition to Wilms tumor; Identify the genetic or epigenetic mechanism for Wilms tumor; and Determine risks for additional medical complications.

GOAL 4:

Discuss genetic counseling issues including mode of inheritance, recurrence risk, and evaluation of relatives at risk based on the underlying genetic mechanism.

GOAL 5:

Discuss management (e.g., tumor screening) recommendations for individuals with a genetic predisposition to Wilms tumor.

Copyright © 1993-2018, University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved.

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