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Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a000539. doi: 10.1101/cshperspect.a000539.

The nuclear envelope.

Author information

1
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California 92037, USA. hetzer@salk.edu

Abstract

The nuclear envelope (NE) is a highly regulated membrane barrier that separates the nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different proteins that have been implicated in chromatin organization and gene regulation. Although the nuclear membrane enables complex levels of gene expression, it also poses a challenge when it comes to cell division. To allow access of the mitotic spindle to chromatin, the nucleus of metazoans must completely disassemble during mitosis, generating the need to re-establish the nuclear compartment at the end of each cell division. Here, I summarize our current understanding of the dynamic remodeling of the NE during the cell cycle.

PMID:
20300205
PMCID:
PMC2829960
DOI:
10.1101/cshperspect.a000539
[Indexed for MEDLINE]
Free PMC Article

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