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J Autism Dev Disord. 2010 Sep;40(9):1139-45. doi: 10.1007/s10803-010-0961-7.

Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder.

Author information

1
Department of Psychiatry, Stony Brook University, New York, NY, USA. kenneth.gadow@stonybrook.edu

Abstract

Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive-compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.

PMID:
20155310
PMCID:
PMC4348063
DOI:
10.1007/s10803-010-0961-7
[Indexed for MEDLINE]
Free PMC Article

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