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J Clin Invest. 2010 Jan;120(1):60-70. doi: 10.1172/JCI41158.

Enabling stem cell therapies through synthetic stem cell-niche engineering.

Author information

1
Institute of Biomaterials and Biomedical Engineering, and Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.

Abstract

Enabling stem cell-targeted therapies requires an understanding of how to create local microenvironments (niches) that stimulate endogenous stem cells or serve as a platform to receive and guide the integration of transplanted stem cells and their derivatives. In vivo, the stem cell niche is a complex and dynamic unit. Although components of the in vivo niche continue to be described for many stem cell systems, how these components interact to modulate stem cell fate is only beginning to be understood. Using the HSC niche as a model, we discuss here microscale engineering strategies capable of systematically examining and reconstructing individual niche components. Synthetic stem cell-niche engineering may form a new foundation for regenerative therapies.

PMID:
20051637
PMCID:
PMC2798701
DOI:
10.1172/JCI41158
[Indexed for MEDLINE]
Free PMC Article

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