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Am J Transl Res. 2009 Mar 5;1(3):221-34.

Genetics of coronary artery disease: focus on genome-wide association studies.

Author information

1
Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, MN.

Abstract

With the advent of the genome-wide association (GWA) study, a promising new avenue for identifying genetic markers for complex diseases like coronary artery disease (CAD) has been opened. This avenue, however, is not without challenges and limitations, including the need for carefully designed and executed studies and the risk of false positive associations. Nonetheless, new markers have been identified through such studies that could potentially revolutionize the ways that individuals with CAD are identified and managed.

KEYWORDS:

atherosclerosis; coronary artery disease; genetics; genome wide association; genomics; myocardial infarction

PMID:
19956433
PMCID:
PMC2776326

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