A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch

J Vet Med Sci. 2010 Feb;72(2):229-34. doi: 10.1292/jvms.09-0235. Epub 2009 Nov 25.

Abstract

We report a rare case of benign sex cord-stromal tumor consisted largely of luteoma with minor portion of Sertoli cell tumor located at the position of the left ovary excision in an 11-year-old ovariectomized bitch. Granulosa cell component was lacking, and both luteal and Sertoli cell portions were entirely positive for inhibin alpha and neuron-specific enolase, whereas luteoma portion alone was positive for Wilms' tumor-1 (WT1), immunohistochemically. The results suggest that this tumor is a possible complication of incomplete ovarian excision at the time of ovariectomy and consisted of uncommon hybrid of luteal and Sertoli cells to be diagnosed as an unclassified sex cord-stromal tumor if applied in human cases. WT1-expression pattern suggested the signature of the difference in the phenotype of these cell types.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Dogs
  • Female
  • Immunohistochemistry / veterinary
  • Luteal Cells / pathology
  • Male
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / veterinary*
  • Sertoli Cells / pathology
  • Sex Cord-Gonadal Stromal Tumors / pathology
  • Sex Cord-Gonadal Stromal Tumors / veterinary*