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Muscle Nerve. 2010 Jan;41(1):110-3. doi: 10.1002/mus.21526.

Ros-mediated activation of NF-kappaB and Foxo during muscle disuse.

Author information

1
Department of Applied Physiology and Kinesiology, University of Florida, P.O. Box 118205, Gainesville, Florida 32611, USA. sdodd@hhp.ufl.edu

Abstract

We examined reactive oxygen species as upstream activators of nuclear factor kappaB; (NF-kappaB) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Catalase, an enzyme that degrades H2O2, was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization-induced transactivation of both NF-kappaB and Foxo and attenuated the loss of muscle mass. Thus, H2O2 may be an important initiator of these signaling pathways that lead to muscle atrophy.

PMID:
19813194
PMCID:
PMC2796694
DOI:
10.1002/mus.21526
[Indexed for MEDLINE]
Free PMC Article

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