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J Inorg Biochem. 2009 Sep;103(9):1196-203. doi: 10.1016/j.jinorgbio.2009.05.017. Epub 2009 Jun 11.

Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity.

Author information

1
Department of Science, Institute of Technology Tallaght, Dublin, Ireland. bernie.creaven@it-tallaght.ie

Erratum in

  • J Inorg Biochem. 2009 Dec;103(12):1761.

Abstract

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.

PMID:
19631386
DOI:
10.1016/j.jinorgbio.2009.05.017
[Indexed for MEDLINE]

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