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Ann Thorac Surg. 2009 Jun;87(6):1941-3. doi: 10.1016/j.athoracsur.2008.11.005.

An unusual presentation of spontaneous pneumothorax secondary to talc-induced pulmonary granulomatosis.

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Department of Cardiothoracic Surgery, Appalachian Regional Healthcare, Hazard, Kentucky, USA.


Talc-induced pulmonary granulomatosis is an unusual condition resulting from the intravenous administration of medications intended for oral use. A patient with this condition who presented with a spontaneous tension pneumothorax is reported. Although the radiographic findings of a diffuse reticulonodular pattern are typical, this patient was found to have diffuse, small cavitary pulmonary nodules. Surgeons should be aware of this rare condition and should have a low threshold for performing a thoracoscopic lung biopsy.

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