Cathepsin K: a therapeutic target for bone diseases

Qingxiao Zhao; Yanping Jia; Yongtao Xiao

doi:10.1016/j.bbrc.2009.01.139

Cathepsin K: a therapeutic target for bone diseases

Biochem Biophys Res Commun. 2009 Mar 20;380(4):721-3. doi: 10.1016/j.bbrc.2009.01.139. Epub 2009 Jan 27.

Authors

Qingxiao Zhao¹, Yanping Jia, Yongtao Xiao

Affiliation

¹ College of Chemical Engineering, Northeast Dianli University, Jilin, PR China.

PMID: 19338743
DOI: 10.1016/j.bbrc.2009.01.139

Abstract

Cathepsin K is a member of the papain family of cysteine proteases and is highly expressed in osteoclasts that mediate bone resorption. In this review, some of the known features of cathepsin K such as structure, function in bone resorption, gene regulation and its roles in physiological or pathophysiological processes are highlighted.

Publication types

Review

MeSH terms

Bone Resorption / drug therapy*
Bone Resorption / enzymology*
Bone Resorption / genetics
Cathepsin K
Cathepsins / antagonists & inhibitors*
Cathepsins / genetics
Cathepsins / metabolism*
Dysostoses / genetics
Gene Expression Regulation
Humans
Osteoclasts / enzymology*
Protein Conformation
Tissue Distribution

Substances

Cathepsins
CTSK protein, human
Cathepsin K