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Cell. 2009 Mar 6;136(5):816-8. doi: 10.1016/j.cell.2009.02.029.

PPTR-1 counterAkts insulin signaling.

Abstract

The serine/threonine kinase Akt is a focal point in signaling pathways that control cell tumorigenesis and insulin resistance. In this issue, Padmanabhan et al. (2009) identify a phosphatase regulatory subunit PPTR-1 that regulates the insulin/insulin-like growth factor 1 pathway by counteracting Akt activity in worms and mammalian cells.

PMID:
19269361
DOI:
10.1016/j.cell.2009.02.029
[Indexed for MEDLINE]
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