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J Nat Prod. 2009 Apr;72(4):650-5. doi: 10.1021/np800716f.

Acylated iridoids with cytotoxicity from Valeriana jatamansi.

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1
Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.

Erratum in

  • J Nat Prod. 2014 Nov 26;77(11):2575.

Abstract

Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.

PMID:
19245261
DOI:
10.1021/np800716f
[Indexed for MEDLINE]

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