Format

Send to

Choose Destination
Trends Pharmacol Sci. 2009 Feb;30(2):61-5. doi: 10.1016/j.tips.2008.11.003. Epub 2009 Jan 8.

Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use.

Author information

1
Institute of Cell Biology, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland. jessberger@cell.biol.ethz.ch

Abstract

Adult hippocampal stem/progenitor cells (AHPs) continuously give rise to new neurons throughout life, which might be an important determinant of hippocampus-dependent function. Strikingly, the fate potential of AHPs is not restricted to the neuronal lineage because AHPs can be genetically induced to generate oligodendrocytes within their in vivo niche by AHP-specific ectopic expression of the basic-helix-loop-helix (bHLH) transcription factor achaete-scute complex-like 1 (ASCL1). Fate plasticity of AHPs is controlled by cell-autonomous and also niche-dependent mechanisms. Here, we discuss the biological importance and potential therapeutic applications of retained fate plasticity of AHPs in the adult mammalian brain in addition to the future scientific inquiries indicated by this finding.

PMID:
19135265
PMCID:
PMC2752320
DOI:
10.1016/j.tips.2008.11.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center