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Cell Metab. 2008 Nov;8(5):343-4. doi: 10.1016/j.cmet.2008.10.007.

Raptor swoops in on metabolism.

Author information

1
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. shaw@salk.edu

Abstract

The mammalian target of rapamycin (mTOR) serine/threonine kinase plays a central role in insulin signaling and cell growth, through two distinct complexes with its subunits raptor or rictor. In this issue, two reports utilizing tissue-specific knockout mice detail key roles for mTORC1 in skeletal muscle and adipose tissue function.

PMID:
19046565
DOI:
10.1016/j.cmet.2008.10.007
[Indexed for MEDLINE]
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