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J Pediatr. 2009 Apr;154(4):562-566.e1. doi: 10.1016/j.jpeds.2008.09.055. Epub 2008 Nov 22.

Increased prevalence of abnormal glucose tolerance among obese siblings of children with type 2 diabetes.

Author information

1
Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. magge@email.chop.edu

Abstract

OBJECTIVE:

To test the hypothesis that overweight siblings of children with type 2 diabetes mellitus (T2DM) have a higher prevalence of abnormal glucose tolerance (AGT) compared with other overweight children.

STUDY DESIGN:

This was a cross-sectional study of overweight (body mass index [BMI] >or= 95(th) percentile) subjects, age 8 to 17 years, with at least 1 sibling age >or= 12 years. The primary outcome was AGT, as assessed by the oral glucose tolerance test (2-hour glucose >or= 140 mg/dL). The secondary outcome was insulin resistance by homeostasis model assessment (HOMA).

RESULTS:

The sibling (n=20) and control (n=42) groups were similar in terms of age, sex, racial distribution (largely African American), pubertal status, and BMI. The prevalence of AGT in the sibling group was 40.0% (n=8), compared with 14.3% (n=6) in controls (P= .048, Fisher exact test; unadjusted odds ratio=4.0; 95% confidence interval=1.2 to 13.5). Univariate analysis did not identify confounders for either outcome. There were no significant differences in HOMA or hemoglobin A1c between the 2 groups.

CONCLUSIONS:

Overweight siblings of children with T2DM had 4 times greater odds of having AGT compared with other overweight children. This group may represent a particularly high-risk population to target for screening and pediatric T2DM prevention.

PMID:
19028390
PMCID:
PMC2746396
DOI:
10.1016/j.jpeds.2008.09.055
[Indexed for MEDLINE]
Free PMC Article

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