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Nat Chem Biol. 2009 Jan;5(1):23-5. doi: 10.1038/nchembio.126. Epub 2008 Nov 16.

Peptidase substrates via global peptide profiling.

Author information

1
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Abstract

Peptide metabolism is a complex process that involves many proteins working in concert. Mass spectrometry-based global peptide profiling of mice lacking dipeptidyl peptidase 4 (DPP4) identified endogenous DPP4 substrates and revealed an unrecognized pathway during proline peptide catabolism that interlinks aminopeptidase and DPP4 activities. Together, these studies elucidate specific aspects of DPP4-regulated metabolism and, more generally, highlight the utility of global peptide profiling for studying peptide metabolism in vivo.

PMID:
19011639
PMCID:
PMC2730040
DOI:
10.1038/nchembio.126
[Indexed for MEDLINE]
Free PMC Article

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