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1943 2
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1945 93
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The following term was not found in PubMed: 18f-alphavbeta6-binding
Page 1
Peptide chemistry toolbox - Transforming natural peptides into peptide therapeutics.
Erak M, Bellmann-Sickert K, Els-Heindl S, Beck-Sickinger AG. Erak M, et al. Bioorg Med Chem. 2018 Jun 1;26(10):2759-2765. doi: 10.1016/j.bmc.2018.01.012. Epub 2018 Jan 31. Bioorg Med Chem. 2018. PMID: 29395804 Review.
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. ...In this mini-review, we present a toolbox of modifications in peptide chemistry for overcoming the main drawbacks …
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicin …
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.
Tanada M, Tamiya M, Matsuo A, Chiyoda A, Takano K, Ito T, Irie M, Kotake T, Takeyama R, Kawada H, Hayashi R, Ishikawa S, Nomura K, Furuichi N, Morita Y, Kage M, Hashimoto S, Nii K, Sase H, Ohara K, Ohta A, Kuramoto S, Nishimura Y, Iikura H, Shiraishi T. Tanada M, et al. J Am Chem Soc. 2023 Aug 2;145(30):16610-16620. doi: 10.1021/jacs.3c03886. Epub 2023 Jul 18. J Am Chem Soc. 2023. PMID: 37463267
Here, starting with a drug-like hit discovered using an mRNA display library, we describe a chemical optimization that led to the orally available clinical compound known as LUNA18, an 11-mer cyclic peptide inhibitor for the intracellular tough target RAS. The key findings …
Here, starting with a drug-like hit discovered using an mRNA display library, we describe a chemical optimization that led to the orally ava …
Peptide Arrays for Binding Studies of E3 Ubiquitin Ligases.
Klecker M, Dissmeyer N. Klecker M, et al. Methods Mol Biol. 2016;1450:85-94. doi: 10.1007/978-1-4939-3759-2_7. Methods Mol Biol. 2016. PMID: 27424747
Several hundreds of peptide sequences can be assembled with this technique on one membrane comprising a strong binding potential due to high local peptide concentrations. ...Pioneer studies described binding capability of mammalian and yeast enzymes depending on a …
Several hundreds of peptide sequences can be assembled with this technique on one membrane comprising a strong binding potential due …
Peptide-based covalent inhibitors of protein-protein interactions.
Paulussen FM, Grossmann TN. Paulussen FM, et al. J Pept Sci. 2023 Jan;29(1):e3457. doi: 10.1002/psc.3457. Epub 2022 Nov 9. J Pept Sci. 2023. PMID: 36239115 Free PMC article. Review.
However, certain proteins remain challenging targets when applying inhibitors with a competitive mode of action. For that reason, peptide-based ligands with an irreversible binding mode have gained attention in recent years. This review summarizes examples of covalent inhi …
However, certain proteins remain challenging targets when applying inhibitors with a competitive mode of action. For that reason, peptide …
Mechanisms Inspired Targeting Peptides.
Yuan Y. Yuan Y. Adv Exp Med Biol. 2020;1248:531-546. doi: 10.1007/978-981-15-3266-5_21. Adv Exp Med Biol. 2020. PMID: 32185724 Review.
Peptides, as a large group of molecules, are composed of amino acid residues and can be divided into linear or cyclic peptides according to the structure. Over 13,000 molecules of natural peptides have been found and many of them have been well studied. In ar …
Peptides, as a large group of molecules, are composed of amino acid residues and can be divided into linear or cyclic peptides …
Peptide-based coacervates as biomimetic protocells.
Abbas M , Lipiński WP , Wang J , Spruijt E . Abbas M , et al. Chem Soc Rev. 2021 Mar 21;50(6):3690-3705. doi: 10.1039/d0cs00307g. Epub 2021 Feb 22. Chem Soc Rev. 2021. PMID: 33616129 Review.
The main advantage of peptides as building blocks lies in the functional diversity of the amino acid residues, which allows for tailoring of the peptide's phase separation propensity, their selectivity in guest molecule uptake and the physicochemical and cata …
The main advantage of peptides as building blocks lies in the functional diversity of the amino acid residues, which allows for tailo …
Exploring Photoswitchable Binding Interactions with Small-Molecule- and Peptide-Based Inhibitors of Trypsin.
Palasis KA, Peddie V, Turner DJL, Zhang X, Yu J, Abell AD. Palasis KA, et al. Chembiochem. 2023 Oct 17;24(20):e202300453. doi: 10.1002/cbic.202300453. Epub 2023 Sep 4. Chembiochem. 2023. PMID: 37584529
The best peptidic inhibitor displayed a more than fivefold difference in inhibitory activity between isomeric states, whereas the best small-molecule inhibitor only showed a 3.4-fold difference. Docking and molecular modelling suggest this result is due to a large change i …
The best peptidic inhibitor displayed a more than fivefold difference in inhibitory activity between isomeric states, whereas the bes …
Folding-Mediated DNA Delivery by alpha-Helical Amphipathic Peptides.
Noble JE, Vila-Gómez P, Rey S, Dondi C, Briones A, Aggarwal P, Hoose A, Baran M, Ryadnov MG. Noble JE, et al. ACS Biomater Sci Eng. 2023 May 8;9(5):2584-2595. doi: 10.1021/acsbiomaterials.3c00221. Epub 2023 Apr 4. ACS Biomater Sci Eng. 2023. PMID: 37014978
Several peptidic reagents have been commercialized to date. However, a comparative assessment of peptide sequences alone without auxiliary support or excipients against a common determinant for their ability to complex and deliver DNA has been lacking. ...Peptide …
Several peptidic reagents have been commercialized to date. However, a comparative assessment of peptide sequences alone witho …
Strategies to Enhance Metabolic Stabilities.
Khatri B, Nuthakki VR, Chatterjee J. Khatri B, et al. Methods Mol Biol. 2019;2001:17-40. doi: 10.1007/978-1-4939-9504-2_2. Methods Mol Biol. 2019. PMID: 31134565 Review.
Macrocyclic peptides are a unique class of molecules that display a relatively constrained peptidic backbone as compared to their linear counterparts leading to the defined 3-D orientation of the constituent amino acids (pharmacophore). ...In this chapter we review …
Macrocyclic peptides are a unique class of molecules that display a relatively constrained peptidic backbone as compared to th …
Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles.
D'Amore VM, Donati G, Lenci E, Ludwig BS, Kossatz S, Baiula M, Trabocchi A, Kessler H, Di Leva FS, Marinelli L. D'Amore VM, et al. J Chem Inf Model. 2023 Oct 23;63(20):6302-6315. doi: 10.1021/acs.jcim.3c01071. Epub 2023 Oct 3. J Chem Inf Model. 2023. PMID: 37788340 Free PMC article.
Receptor-selective peptides are widely used as smart carriers for specific tumor-targeted delivery. ...Furthermore, we use parallel tempering in the well-tempered ensemble (PT-WTE) metadynamics simulations to characterize the in-solution conformation of iRGD and extensive …
Receptor-selective peptides are widely used as smart carriers for specific tumor-targeted delivery. ...Furthermore, we use parallel t …
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