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Arch Intern Med. 1991 Feb;151(2):373-4.

Diltiazem-induced psychosis and a possible diltiazem-lithium interaction.

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Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo.


Calcium channel blockers are being used increasingly for a variety of cardiovascular problems. Diltiazem hydrochloride, a benzothiazepine derivative, has been reported to have a low incidence of adverse side effects. We report a case of acute psychosis associated with the use of diltiazem in a patient receiving lithium carbonate therapy. Both diltiazem hydrochloride and lithium carbonate have calcium antagonist effects in the central nervous system, and we review their mechanisms of action. A possible synergistic drug interaction between diltiazem and lithium is reported.

[Indexed for MEDLINE]

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