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AIDS. 2008 Oct 18;22(16):2214-7. doi: 10.1097/QAD.0b013e328314b5df.

Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.

Author information

1
Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK.

Abstract

Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/l). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV, defined by 2G12, is more widespread amongst immunogenic, microbial surfaces than previously recognized.

PMID:
18832887
DOI:
10.1097/QAD.0b013e328314b5df
[Indexed for MEDLINE]

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