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Bioorg Med Chem Lett. 2008 Aug 15;18(16):4482-5. doi: 10.1016/j.bmcl.2008.07.061. Epub 2008 Jul 17.

4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors.

Author information

1
Oncology Division, Novartis Institutes of Biomedical Research, 4560 Horton Street, Emeryville, CA 94608, USA. cynthia_shafer@chiron.com

Abstract

A series of 4-(4-hydroxyphenyl)-6-phenylpyrimidin-2(1H)-ones were identified by HTS as inhibitors of CDC7. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus on removing potential metabolic liabilities and improving cellular potency.

PMID:
18672368
DOI:
10.1016/j.bmcl.2008.07.061
[Indexed for MEDLINE]

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